氧感应通路与肿瘤细胞对放疗和化疗的耐药作用有关。随着肿瘤的成长
，肿瘤细胞能够感应到环境中氧气的严重并沉新编程与癌细胞生计和医治抵抗亲昵有关的关键蹊径。这种沉新编程的其中一个例子是通过上调缺氧诱导因子α（HIF-alpha）和激活HIF信号下游通路。

张博士的尝试室重要致力于钻研氧感应通路
，以及它们若何推进肿瘤的发展以及医治耐药。张博士的尝试室在执行新的基因组和蛋白质组学步骤
，以确定乳腺癌和肾癌中氧感应信号的沉要新医治靶点。在本次云讲堂直播间
，张博士将为我们带来萦绕氧感应通路而发现的医治新靶点
，蕴含乳腺癌新靶点BBOX1以及肾癌新靶点ZHX2、SFMBT1、TBK1等。

09月10日晚19:00--20:00
，张青教授将为我们带来《乳腺癌和肾癌医治新靶点的发现和确证》
，欢迎各人定时收看！

Hypoxia is associated with resistance towards radiation and chemotherapy. As tumors grow, they can sense the oxygen tension and reprogram critical pathways that are important for cancer cell survival and therapy resistance. One of examples is through upregulation of hypoxia inducible factor alpha (HIF-α) and activation of HIF signaling downstream pathways. Dr. Zhang’s lab is mainlyinterested in studying the oxygen-sensing pathway and how they contribute tothe development of tumors as well as therapeutic resistance. Dr. Zhang’s lab is implementing novel genomic and proteomic approaches to identify important new therapeutic targets in oxygen sensing signaling in breast and kidney cancers. During this talk, Dr. Zhang will present on identifying BBOX1 as a new therapeutic target in breast cancer. In addition, Dr. Zhang will present on identifying a few new therapeutic targets in kidney cancer, including ZHX2,SFMBT1 and TBK1.